Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i

Authors: Makoto Harada, Jonathan Adam, Marcela Covic, Jianhong Ge, Stefan Brandmaier, Caroline Muschet, Jialing Huang, Siyu Han, Martina Rommel, Markus Rotter, Margit Heier, Robert P. Mohney, Jan Krumsiek, Gabi Kastenmüller, Wolfgang Rathmann, Zhongmei Zou, Sven Zukunft, Markus F. Scheerer, Susanne Neschen, Jerzy Adamski, Christian Gieger, Annette Peters, Donna P. Ankerst, Thomas Meitinger, Tanya L. Alderete, Martin Hrabe de Angelis Karsten Suhre and Rui Wang-Sattler   Harada et al. Cardiovascular Diabetology (2024) 23:199 doi: https://doi.org/10.1186/s12933-024-02288-x Published: 12 June 2024   Abstract: Background Metformin and sodium-glucose-cotransporter-2…

Prediction of Myocardial Infarction Using a Combined Generative Adversarial Network Model and Feature-Enhanced Loss Function

Authors: Shixiang Yu, Siyu Han, Mengya Shi, Makoto Harada, Jianhong Ge, Xuening, Xiang Cai, Margit Heier, Gabi Karstenmüller, Karsten Suhre, Christian Gieger, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters and Rui Wang-Sattler   Metabolites 2024, 14, 258. doi: https://doi.org/10.3390/ metabo14050258 Published: 30 April 2024   Abstract: Accurate risk prediction for myocardial infarction (MI) is crucial for…

LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer

Authors: Siyu Han, Shixiang Yu, Mengya Shi, Makoto Harada, Jianhong Ge, Jiesheng Lin, Cornelia Prehn, Agnese Petrera, Ying Li, Flora Sam, Giuseppe Matullo, Jerzy Adamski, Karsten Suhre, Christian Gieger, Stefanie M. Hauck, Christian Herder, Michael Roden, Francesco Paolo Casale, Na Cai, Annette Peters, Rui Wang-Sattler   Nature Communications doi: 10.1038/s41467-025-58314-3 Published: 1 June 2024   Abstract:…

Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts

Authors: Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone, Shixiang Yu, Makoto Harada, Ann‑Kristin Henning, Nele Friedrich, Martin Bahls, Marcus Dörr, Matthias Nauck, Henry Völzke, Georg Homuth, Hans J. Grabe, Cornelia Prehn, Jerzy Adamski, Karsten Suhre, Wolfgang Rathmann, Andreas Ruepp, Johannes Hertel, Annette Peters and Rui Wang‑Sattler     Shi et al. Cardiovascular…

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Authors: Jolanda van der Velden, Folkert W. Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R. Bezzina, Ilze Bot, Bianca J.J.M. Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli Dana Dawson, Sean M. Davidson, Andreas Dendorfer, Dirk J. Duncker, Thomas Eschenhagen, Larissa Fabritz, Ines Falcao-Pires, Peter Ferdinandy, Mauro Giacca, Henrique Girao, Can Gollmann-Tepeköylü, Mariann Gyongyosi, Tomasz…

TIGER: technical variation elimination for metabolomics data using ensemble learning architecture

Authors: Siyu Han, Jialing Huang, Francesco Foppiano, Cornelia Prehn, Jerzy Adamski, Karsten Suhre, Ying Li, Giuseppe Matullo, Freimut Schliess, Christian Gieger, Annette Peters and Rui Wang-Sattler   Briefings in Bioinformatics, 2022, 23(2), 1–16 doi: https://doi.org/10.1093/cvr/cvaa110 Published: 3 January 2022   Abstract: Large metabolomics datasets inevitably contain unwanted technical variations which can obscure meaningful biological signals…

Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Authors: Serena Zacchigna, Alessia Paldino, Inês Falcao-Pires, Evangelos P. Daskalopoulos, Matteo Dal Ferro, Simone Vodret , Pierluigi Lesizza, Antonio Cannata, Daniela Miranda-Silva, André P. Lourenco, Bruno Pinamonti , Gianfranco Sinagra , Florian Weinberger, Thomas Eschenhagen, Lucie Carrier, Izhak Kehat, Carlo G. Tocchetti, Michele Russo, Alessandra Ghigo, James Cimino, Emilio Hirsch, Dana Dawson, Michele Ciccarelli, Marco…

Risk of bias in studies investigating novel diagnostic biomarkers for heart failure with preserved ejection fraction. A systematic review

Authors: Michiel T.H.M. Henkens, Sharon Remmelzwaal, Emma L. Robinson, Adriana J. van Ballegooijen, Arantxa Barandiarán Aizpurua, Job A.J. Verdonschot,  Anne G. Raafs, Jerremy Weerts, Mark R. Hazebroek, Sandra Sanders-van Wijk, M. Louis Handoko, Hester M. den Ruijter, Carolyn S.P. Lam, Rudolf A. de Boer, Walter J. Paulus,Vanessa P.M. van Empel, Rein Vos, Hans-Peter Brunner-La Rocca1,…