{"id":664,"date":"2023-07-12T16:08:00","date_gmt":"2023-07-12T14:08:00","guid":{"rendered":"https:\/\/cardiateam.eu\/?page_id=664"},"modified":"2025-08-27T17:50:36","modified_gmt":"2025-08-27T15:50:36","slug":"clinical-study","status":"publish","type":"page","link":"https:\/\/cardiateam.eu\/index.php\/clinical-study\/","title":{"rendered":"Clinical Study"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"664\" class=\"elementor elementor-664\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c569651 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c569651\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-31d5a9f\" data-id=\"31d5a9f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-842940e elementor-widget elementor-widget-spacer\" data-id=\"842940e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ae79fc elementor-widget elementor-widget-spacer\" data-id=\"2ae79fc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-482acff elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"482acff\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;slideInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-xxl\">OUR CLINICAL STUDY<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c0c6bd elementor-widget elementor-widget-spacer\" data-id=\"2c0c6bd\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6c7ed4 elementor-align-center transparence-btn elementor-widget elementor-widget-button\" data-id=\"d6c7ed4\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/cardiateam.eu\/index.php\/projets-utilisant-les-donnees-issues-de-la-recherche-cardiateam\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Calque_1\" viewBox=\"0 0 30 30\"><defs><style>      .st0 {        fill: #6f9635;      }    <\/style><\/defs><path class=\"st0\" 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class=\"elementor-button-text\"><strong>Acc\u00e9der aux projets utilisant les donn\u00e9es issues de la recherche Cardiateam<\/strong><br \/>(portail de transparence)<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e87fc3b elementor-widget elementor-widget-spacer\" data-id=\"e87fc3b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe5a263 elementor-widget elementor-widget-spacer\" data-id=\"fe5a263\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div 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class=\"elementor-element elementor-element-03f4a13 elementor-widget elementor-widget-spacer\" data-id=\"03f4a13\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bae03ad elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"bae03ad\" data-element_type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-1951\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-1951\" aria-expanded=\"false\">\ud83c\uddeb\ud83c\uddf7 <\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-1952\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1952\" aria-expanded=\"false\">\ud83c\uddec\ud83c\udde7<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-1953\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1953\" aria-expanded=\"false\">\ud83c\udde9\ud83c\uddea<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-1954\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1954\" aria-expanded=\"false\">\ud83c\uddea\ud83c\uddf8<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-1951\" aria-expanded=\"false\">\ud83c\uddeb\ud83c\uddf7 <\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1951\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1951\" tabindex=\"0\" hidden=\"false\"><p>L&#8217;objectif principal de cette \u00e9tude est de d\u00e9terminer dans quelle mesure les changements conduisant \u00e0 un d\u00e9clin de la fonction cardiaque chez les patients atteints de DT2 (cardiomyopathie diab\u00e9tique) sont uniques et distincts des autres troubles cardiaques. L&#8217;hypoth\u00e8se de l&#8217;\u00e9tude CARDIATEAM est que la cardiomyopathie diab\u00e9tique est le r\u00e9sultat de la d\u00e9r\u00e9gulation de m\u00e9canismes biologiques (signalisation sp\u00e9cifique \u00e0 identifier) conduisant \u00e0 un dysfonctionnement cardiaque particulier qui n&#8217;est pas le m\u00eame que pour les autres formes d&#8217;insuffisance cardiaque.<\/p><p>Lorsque le caract\u00e8re unique de la cardiomyopathie diab\u00e9tique sera confirm\u00e9, cette \u00e9tude aura \u00e9galement pour objectif de classer les patients diab\u00e9tiques en fonction de leur risque plus ou moins \u00e9lev\u00e9 de d\u00e9velopper une insuffisance cardiaque afin d&#8217;am\u00e9liorer leur traitement par rapport aux sch\u00e9mas de prise en charge de cette maladie existant en Europe.\u00a0<\/p><p>En r\u00e9sum\u00e9, les r\u00e9sultats de cette \u00e9tude visent \u00e0 am\u00e9liorer la prise en charge clinique des patients DT2 en les exposant \u00e0 des strat\u00e9gies pr\u00e9ventives et th\u00e9rapeutiques personnalis\u00e9es afin de pr\u00e9server au mieux leur fonction cardiaque.<\/p><p><strong><em>Pour en savoir plus, <a href=\"#france\">cliquez ici<\/a>.<\/em><\/strong><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1952\" aria-expanded=\"false\">\ud83c\uddec\ud83c\udde7<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1952\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1952\" tabindex=\"0\" hidden=\"hidden\"><p>The main objective of this study is to determine the extent to which the changes leading to a decline in cardiac function in patients with T2DM (diabetic cardiomyopathy) are unique and distinct from other cardiac disorders. The hypothesis of the CARDIATEAM study is that diabetic cardiomyopathy is the result of the deregulation of biological mechanisms (specific signaling to be identified) leading to a particular cardiac dysfunction that is not the same as for other forms of heart failure.<\/p><p>When the uniqueness of diabetic cardiomyopathy is confirmed, this study will also aim to classify diabetic patients according to their greater or lesser risk of developing heart failure to improve their treatment compared to existing management regimens for this disease in Europe.\u00a0<\/p><p>In summary, the results of this study aim to improve clinical care for T2DM patients by exposing them to personalized preventive and therapeutic strategies to best preserve their cardiac function.<\/p><p><em><strong>Click here to <a href=\"#unitedkingdom\">read more.<\/a><\/strong><\/em><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1953\" aria-expanded=\"false\">\ud83c\udde9\ud83c\uddea<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1953\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1953\" tabindex=\"0\" hidden=\"hidden\"><p>Das Hauptziel dieser Studie ist es, festzustellen, inwieweit die Ver\u00e4nderungen, die zu einer Verschlechterung der Herzfunktion bei Patienten mit T2DM (diabetische Kardiomyopathie) f\u00fchren, einzigartig sind und sich von anderen Herzerkrankungen unterscheiden. Die Hypothese der CARDIATEAM-Studie ist, dass die diabetische Kardiomyopathie das Ergebnis einer Deregulierung biologischer Mechanismen ist (spezifische Signal\u00fcbertragung muss noch identifiziert werden), die zu einer besonderen Herzfunktionsst\u00f6rung f\u00fchrt, die sich von anderen Formen der Herzinsuffizienz unterscheidet.<\/p><p>Wenn die Einzigartigkeit der diabetischen Kardiomyopathie best\u00e4tigt wird, wird diese Studie auch darauf abzielen, Diabetespatienten nach ihrem gr\u00f6\u00dferen oder geringeren Risiko f\u00fcr die Entwicklung einer Herzinsuffizienz zu klassifizieren, um ihre Behandlung im Vergleich zu den bestehenden Behandlungsschemata f\u00fcr diese Krankheit in Europa zu verbessern.\u00a0<\/p><p>Zusammenfassend l\u00e4sst sich sagen, dass die Ergebnisse dieser Studie darauf abzielen, die klinische Versorgung von T2DM-Patienten zu verbessern, indem ihnen personalisierte Pr\u00e4ventions- und Therapiestrategien angeboten werden, um ihre Herzfunktion bestm\u00f6glich zu erhalten.<\/p><p><em><strong>Weitere Informationen<\/strong> <a href=\"#deutschland\"><strong>finden Sie hier.<\/strong> <\/a><\/em><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-1954\" aria-expanded=\"false\">\ud83c\uddea\ud83c\uddf8<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1954\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1954\" tabindex=\"0\" hidden=\"hidden\"><p>La hip\u00f3tesis de CARDIATEAM es que la miocardiopat\u00eda diab\u00e9tica es el resultado de la desregulaci\u00f3n de mecanismos biol\u00f3gicos espec\u00edficos que conducen a una disfunci\u00f3n cardiaca \u00fanica y, por tanto, diferente de otras formas de insuficiencia cardiaca.<\/p><p>El objetivo principal de CARDIATEAM es comprender los mecanismos que conducen al desarrollo de la cardiomiopat\u00eda espec\u00edfica de los pacientes diab\u00e9ticos de tipo 2 (DMT2).\u00a0<\/p><p>Los otros objetivos de CARDIATEAM son mejorar la puntuaci\u00f3n predictiva del desarrollo de insuficiencia cardiaca e identificar nuevas dianas terap\u00e9uticas para el desarrollo de tratamientos espec\u00edficos de la miocardiopat\u00eda diab\u00e9tica y mejorar as\u00ed su tratamiento.\u00a0<\/p><p>En resumen, los resultados de este estudio pretenden mejorar el tratamiento cl\u00ednico de los pacientes con DMT2 mediante la detecci\u00f3n precoz de la miocardiopat\u00eda diab\u00e9tica, una entidad a\u00fan poco conocida, y la prevenci\u00f3n de la progresi\u00f3n a insuficiencia cardiaca.<\/p><p><em><strong><span class=\"--l --r sentence_highlight\">Para m\u00e1s informaci\u00f3n, <a href=\"#spain\">pulse aqu\u00ed<\/a><\/span>.<\/strong><\/em><\/p><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3a3aa2b elementor-section-stretched elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a3aa2b\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;wave-brush&quot;,&quot;shape_divider_bottom&quot;:&quot;wave-brush&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 283.5 27.8\" preserveAspectRatio=\"none\">\n\t<path 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class=\"elementor-element elementor-element-420f6ea elementor-widget elementor-widget-spacer\" data-id=\"420f6ea\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a44fa7a elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a44fa7a\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6a852e0\" data-id=\"6a852e0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c77a56 elementor-widget elementor-widget-spacer\" data-id=\"7c77a56\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0a0dced elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0a0dced\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6559a89\" data-id=\"6559a89\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bcfcb9a elementor-widget elementor-widget-spacer\" data-id=\"bcfcb9a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf8f665 elementor-widget elementor-widget-spacer\" data-id=\"bf8f665\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bedf6e6 elementor-widget elementor-widget-menu-anchor\" data-id=\"bedf6e6\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"france\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8ab64c elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"b8ab64c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;slideInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">FRANCE \ud83c\uddeb\ud83c\uddf7<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-632cc74 elementor-widget elementor-widget-text-editor\" data-id=\"632cc74\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #ffffff;\">Cochin, Lariboisi\u00e8re, Mondor, Marseille, Lyon et Grenoble<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c685775 elementor-widget elementor-widget-spacer\" data-id=\"c685775\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7366bd1 elementor-widget elementor-widget-spacer\" data-id=\"7366bd1\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1f725ee elementor-section-stretched elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1f725ee\" data-element_type=\"section\" 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d=\"M283.5,9.7c0,0-7.3,4.3-14,4.6c-6.8,0.3-12.6,0-20.9-1.5c-11.3-2-33.1-10.1-44.7-5.7\ts-12.1,4.6-18,7.4c-6.6,3.2-20,9.6-36.6,9.3C131.6,23.5,99.5,7.2,86.3,8c-1.4,0.1-6.6,0.8-10.5,2c-3.8,1.2-9.4,3.8-17,4.7\tc-3.2,0.4-8.3,1.1-14.2,0.9c-1.5-0.1-6.3-0.4-12-1.6c-5.7-1.2-11-3.1-15.8-3.7C6.5,9.2,0,10.8,0,10.8V0h283.5V9.7z M260.8,11.3\tc-0.7-1-2-0.4-4.3-0.4c-2.3,0-6.1-1.2-5.8-1.1c0.3,0.1,3.1,1.5,6,1.9C259.7,12.2,261.4,12.3,260.8,11.3z M242.4,8.6\tc0,0-2.4-0.2-5.6-0.9c-3.2-0.8-10.3-2.8-15.1-3.5c-8.2-1.1-15.8,0-15.1,0.1c0.8,0.1,9.6-0.6,17.6,1.1c3.3,0.7,9.3,2.2,12.4,2.7\tC239.9,8.7,242.4,8.6,242.4,8.6z M185.2,8.5c1.7-0.7-13.3,4.7-18.5,6.1c-2.1,0.6-6.2,1.6-10,2c-3.9,0.4-8.9,0.4-8.8,0.5\tc0,0.2,5.8,0.8,11.2,0c5.4-0.8,5.2-1.1,7.6-1.6C170.5,14.7,183.5,9.2,185.2,8.5z M199.1,6.9c0.2,0-0.8-0.4-4.8,1.1\tc-4,1.5-6.7,3.5-6.9,3.7c-0.2,0.1,3.5-1.8,6.6-3C197,7.5,199,6.9,199.1,6.9z M283,6c-0.1,0.1-1.9,1.1-4.8,2.5s-6.9,2.8-6.7,2.7\tc0.2,0,3.5-0.6,7.4-2.5C282.8,6.8,283.1,5.9,283,6z 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d=\"M227.4,9.8c-0.2-0.1-4.5-1-9.5-1.2c-5-0.2-12.7,0.6-12.3,0.5c0.3-0.1,5.9-1.8,13.3-1.2\tS227.6,9.9,227.4,9.8z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M204.5,13.4c-0.1-0.1,2-1,3.2-1.1c1.2-0.1,2,0,2,0.3c0,0.3-0.1,0.5-1.6,0.4\tC206.4,12.9,204.6,13.5,204.5,13.4z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M201,10.6c0-0.1-4.4,1.2-6.3,2.2c-1.9,0.9-6.2,3.1-6.1,3.1c0.1,0.1,4.2-1.6,6.3-2.6\tS201,10.7,201,10.6z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M154.5,26.7c-0.1-0.1-4.6,0.3-7.2,0c-7.3-0.7-17-3.2-16.6-2.9c0.4,0.3,13.7,3.1,17,3.3\tC152.6,27.5,154.6,26.8,154.5,26.7z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M41.9,19.3c0,0,1.2-0.3,2.9-0.1c1.7,0.2,5.8,0.9,8.2,0.7c4.2-0.4,7.4-2.7,7-2.6\tc-0.4,0-4.3,2.2-8.6,1.9c-1.8-0.1-5.1-0.5-6.7-0.4S41.9,19.3,41.9,19.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M75.5,12.6c0.2,0.1,2-0.8,4.3-1.1c2.3-0.2,2.1-0.3,2.1-0.5c0-0.1-1.8-0.4-3.4,0\tC76.9,11.5,75.3,12.5,75.5,12.6z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M15.6,13.2c0-0.1,4.3,0,6.7,0.5c2.4,0.5,5,1.9,5,2c0,0.1-2.7-0.8-5.1-1.4\tC19.9,13.7,15.7,13.3,15.6,13.2z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2442544\" data-id=\"2442544\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a0208d3 elementor-widget elementor-widget-spacer\" data-id=\"a0208d3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-37ff9b8 elementor-section-stretched elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"37ff9b8\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;wave-brush&quot;,&quot;shape_divider_bottom&quot;:&quot;wave-brush&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 283.5 27.8\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" 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d=\"M154.5,26.7c-0.1-0.1-4.6,0.3-7.2,0c-7.3-0.7-17-3.2-16.6-2.9c0.4,0.3,13.7,3.1,17,3.3\tC152.6,27.5,154.6,26.8,154.5,26.7z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M41.9,19.3c0,0,1.2-0.3,2.9-0.1c1.7,0.2,5.8,0.9,8.2,0.7c4.2-0.4,7.4-2.7,7-2.6\tc-0.4,0-4.3,2.2-8.6,1.9c-1.8-0.1-5.1-0.5-6.7-0.4S41.9,19.3,41.9,19.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M75.5,12.6c0.2,0.1,2-0.8,4.3-1.1c2.3-0.2,2.1-0.3,2.1-0.5c0-0.1-1.8-0.4-3.4,0\tC76.9,11.5,75.3,12.5,75.5,12.6z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M15.6,13.2c0-0.1,4.3,0,6.7,0.5c2.4,0.5,5,1.9,5,2c0,0.1-2.7-0.8-5.1-1.4\tC19.9,13.7,15.7,13.3,15.6,13.2z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-506641d\" data-id=\"506641d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-70b19d4 elementor-widget elementor-widget-text-editor\" data-id=\"70b19d4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Au cours des derni\u00e8res d\u00e9cennies, il est devenu \u00e9vident qu&#8217;il existe une relation entre le diab\u00e8te sucr\u00e9 de type 2 (DT2) et l&#8217;incapacit\u00e9 du c\u0153ur \u00e0 pomper suffisamment de sang pour r\u00e9pondre aux besoins de l&#8217;organisme, une affection appel\u00e9e insuffisance cardiaque (ICC). Bien que tous les <b>patients atteints de DT2<\/b> ne d\u00e9veloppent pas une maladie affectant la cardiomyopathie, ils <b>ont 2,5 fois<\/b> <b>plus de risques<\/b> que les patients non diab\u00e9tiques <b>d&#8217;\u00e9voluer vers une insuffisance cardiaque<\/b>. Comme pour le diab\u00e8te, d&#8217;autres facteurs tels que l&#8217;hypertension, l&#8217;ob\u00e9sit\u00e9, l&#8217;inflammation et certains troubles g\u00e9n\u00e9tiques peuvent faire \u00e9voluer le patient vers l&#8217;insuffisance cardiaque, et leur pr\u00e9sence simultan\u00e9e n&#8217;a pas encore permis d&#8217;isoler la contribution sp\u00e9cifique du diab\u00e8te sucr\u00e9 de type 2 au d\u00e9veloppement de la cardiomyopathie.<\/p><p><span style=\"color: #8ec044;\">L&#8217;hypoth\u00e8se de l&#8217;\u00e9tude CARDIATEAM<\/span> est que les changements conduisant \u00e0 un d\u00e9clin de la fonction cardiaque chez les patients atteints de DT2 (<b>cardiomyopathie diab\u00e9tique<\/b>) est le r\u00e9sultat de la d\u00e9r\u00e9gulation de m\u00e9canismes biologiques (signalisation sp\u00e9cifique \u00e0 identifier) conduisant \u00e0 un dysfonctionnement cardiaque particulier qui n&#8217;est pas le m\u00eame que pour les autres formes d&#8217;insuffisance cardiaque.<\/p><p><span style=\"color: #8ec044;\">L&#8217;objectif principal de cette \u00e9tude<\/span> est de d\u00e9terminer dans quelle mesure les changements conduisant \u00e0 une cardiomyopathie diab\u00e9tique sont uniques et distincts des autres troubles cardiaques.\u00a0<\/p><p><span style=\"color: #8ec044;\">Objectif secondaire de cette \u00e9tude :<\/span> lorsque le caract\u00e8re unique de la cardiomyopathie diab\u00e9tique sera confirm\u00e9, cette \u00e9tude aura \u00e9galement pour objectif de classer les patients diab\u00e9tiques en fonction de leur risque plus ou moins \u00e9lev\u00e9 de d\u00e9velopper une insuffisance cardiaque afin d&#8217;am\u00e9liorer leur traitement par rapport aux sch\u00e9mas de prise en charge de cette maladie existant en Europe.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d671b11 elementor-widget elementor-widget-text-editor\" data-id=\"d671b11\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">Le c\u0153ur de notre projet CARDIATEAM est une \u00e9tude clinique sur 1600 volontaires qui sont actuellement recrut\u00e9s dans 17 h\u00f4pitaux publics de 5 pays europ\u00e9ens.\u00a0<\/p><p style=\"text-align: center;\">Identifiant ClinicalTrials.gov : NCT04303364<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d89d9c6 elementor-widget elementor-widget-toggle\" data-id=\"d89d9c6\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2271\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2271\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">B\u00e9n\u00e9fices attendus de cette \u00e9tude<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2271\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2271\"><p>Globalement, les r\u00e9sultats de cette \u00e9tude visent \u00e0 <b>am\u00e9liorer la prise en charge clinique des patients DT2<\/b> en les exposant \u00e0 des strat\u00e9gies pr\u00e9ventives et th\u00e9rapeutiques personnalis\u00e9es afin de pr\u00e9server au mieux leur fonction cardiaque. I<\/p><p>Individuellement, chaque volontaire b\u00e9n\u00e9ficiera d\u2019un bilan<b> pouss\u00e9 et de qualit\u00e9 recherche de ses fonctions cardiaques, respiratoires, r\u00e9nales et h\u00e9patiques. <\/b><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2272\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2272\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Cat\u00e9gories de volontaires recherch\u00e9es<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2272\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2272\"><p>Afin de caract\u00e9riser correctement cette <b>cardiomyopathie diab\u00e9tique<\/b>, et de la diff\u00e9rencier potentiellement des autres formes de cardiomyopathie, l&#8217;\u00e9tude <b>CARDIATEAM<\/b> propose de r\u00e9aliser des examens cliniques permettant une caract\u00e9risation plus approfondie de l&#8217;\u00e9tat de sant\u00e9 des patients DT2 et de leurs t\u00e9moins non diab\u00e9tiques tout en recrutant des volontaires dans les 6 groupes suivants :<\/p><ul><li><b>Groupe 1 :<\/b> patients sans diab\u00e8te de type 2 et sans pathologie cardiaque d\u00e9finie comme une insuffisance cardiaque avec fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e.\u00a0Cette population constituera un groupe de r\u00e9f\u00e9rence (contr\u00f4le).<\/li><li><b>Groupe 2 :<\/b> Patients sans diab\u00e8te de type 2 et pr\u00e9sentant une insuffisance cardiaque \u00e0 fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e.<\/li><li><b>Groupe 3 :<\/b> Patients atteints de diab\u00e8te de type 2 et sans insuffisance cardiaque \u00e0 fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e.<\/li><li><b>Groupe 4 :<\/b> Patients atteints de diab\u00e8te de type 2 et souffrant d&#8217;insuffisance cardiaque \u00e0 fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e.<\/li><li><b>Groupe 5 :<\/b> Patients sans diab\u00e8te de type 2 atteints de cardiomyopathie hypertrophique, qui est un autre type de maladie cardiaque (CMH)\u00a0<\/li><li><b>Groupe 6 :<\/b> patients atteints de diab\u00e8te de type 2 et de cardiomyopathie hypertrophique.<\/li><\/ul><p>\u00a0<\/p><p>Lors de la comparaison de tous ces groupes entre eux :<\/p><p>&#8211; Les patients sans diab\u00e8te de type 2 seront les r\u00e9f\u00e9rents\/contr\u00f4les de ceux qui sont diab\u00e9tiques.<\/p><p>&#8211; Les patients sans insuffisance cardiaque \u00e0 fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e \u00b1 DT2 seront les r\u00e9f\u00e9rents\/contr\u00f4les de ceux qui ont une insuffisance cardiaque \u00e0 fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e.<\/p><p>&#8211; Les patients atteints de cardiomyopathie hypertrophique serviront de comparateurs aux groupes de patients souffrant d&#8217;insuffisance cardiaque \u00e0 fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e afin d&#8217;affiner et de mieux d\u00e9finir la singularit\u00e9 de l&#8217;insuffisance cardiaque \u00e0 fraction d&#8217;\u00e9jection pr\u00e9serv\u00e9e par rapport aux autres types de dysfonctionnement myocardique.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2273\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2273\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quels examens seront r\u00e9alis\u00e9s dans le cadre de l'\u00e9tude ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2273\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2273\"><p>Les volontaires souhaitant participer \u00e0 CARDIATEAM passeront une visite de s\u00e9lection afin de d\u00e9terminer s\u2019ils r\u00e9pondent aux crit\u00e8res d&#8217;inclusion\/d\u2019entr\u00e9e dans l\u2019\u00e9tude.\u00a0<\/p><p>Si tel est le cas ils suivront le chemin suivant suivie de :<\/p><p>&#8211; une visite 1 V1 dite d\u2019<b><i>Inclusion\u00a0: <\/i><\/b><i>examens cliniques de routine combin\u00e9s \u00e0 des examens de recherche de qualit\u00e9 clinique, incluant une imagerie extensive afin d\u2019\u00e9valuer les fonctions cardiaque, respiratoire et h\u00e9patique du volontaire. Cette caract\u00e9risation sera coupl\u00e9e \u00e0 des pr\u00e9l\u00e8vements de sang et d\u2019urine afin d\u2019\u00e9valuer la fonction r\u00e9nale et r\u00e9aliser des analyses biologiques innovantes.<\/i><\/p><p>&#8211; deux <b>enqu\u00eates de suivi<\/b> effectu\u00e9es par t\u00e9l\u00e9phone apr\u00e8s un et deux ans apr\u00e8s la V1<\/p><p>&#8211; une visite 2 dite de <b><i>Fin d\u2019\u00e9tude<\/i><\/b>, 3 ans apr\u00e8s la V1<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2274\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2274\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quels sont les h\u00f4pitaux concern\u00e9s ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2274\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2274\"><p><span style=\"color: #8ec044;\"><strong>France :<\/strong> <\/span><\/p><p>&#8211; H\u00f4pital Henri Mondor \u00e0 Cr\u00e9teil<\/p><p>&#8211; H\u00f4pital Cochin \u00e0 Paris<\/p><p>&#8211; H\u00f4pital Lariboisi\u00e8re \u00e0 Paris<\/p><p>&#8211; H\u00f4pital Hospices Civiles de Lyon<\/p><p>&#8211; H\u00f4pital d&#8217;Assistance Publique Marseille\u00a0<\/p><p>&#8211; H\u00f4pital de Nantes<\/p><p>&#8211; H\u00f4pital de Grenoble<\/p><p>\u00a0<\/p><p>Espagne :\u00a0<\/p><p>&#8211; Hospital General Universitario Maranon<\/p><p>&#8211; H\u00f4pital Clinic Barcelona<\/p><p>&#8211; H\u00f4pital Val d&#8217;H\u00e9bron Barcelone<\/p><p>\u00a0<\/p><p>Allemagne :<\/p><p>&#8211; Universit\u00e4tsklinikum Aachen<\/p><p>&#8211; Universit\u00e4tsklinikum Heidelberg<\/p><p>\u00a0<\/p><p>Pays-Bas :<\/p><p>&#8211; H\u00f4pital Maastricht<\/p><p>&#8211; H\u00f4pital d&#8217;Utrecht<\/p><p>&#8211; H\u00f4pital de Groningue<\/p><p>&#8211; H\u00f4pital d&#8217;Amsterdam<\/p><p>\u00a0<\/p><p>Royaume-Uni :<\/p><p>H\u00f4pital Ninewells et facult\u00e9 de m\u00e9decine de Dundee<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2275\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2275\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Comment manifester votre int\u00e9r\u00eat \u00e0 participer \u00e0 l\u2019\u00e9tude CARDIATEAM ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2275\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2275\"><p>Si vous pensez appartenir \u00e0 l\u2019un des 6 groupes de volontaires d\u00e9taill\u00e9s pr\u00e9c\u00e9demment et que vous habitez \u00e0 proximit\u00e9 de l&#8217;un des centres de recrutement cit\u00e9s ci-dessus, n\u2019h\u00e9sitez pas \u00e0 vous renseigner sur la possibilit\u00e9 de participer \u00e0 l&#8217;\u00e9tude en tant que volontaire.<\/p><p>Veuillez nous contacter \u00e0 l&#8217;adresse suivant:\u00a0<b style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\"><a href=\"mailto:cardiateam.imrb@inserm.fr\">cardiateam.imrb@inserm.fr<\/a><\/b><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">\u00a0<\/span><\/p><p>\u00a0<\/p><p>Notre \u00e9quipe se fera un plaisir de vous d\u00e9tailler l&#8217;\u00e9tude et vous proposera peut-\u00eatre un RDV pour une visite d\u2019\u00e9ligibilit\u00e9.<\/p><p>Tout en vous remerciant pour votre engagement citoyen dans la recherche clinique, \u00e0 bient\u00f4t peut-\u00eatre.<\/p><p>\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b134ac elementor-widget 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elementor-element-f7d6ab3 elementor-widget elementor-widget-spacer\" data-id=\"f7d6ab3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a9c0f47 elementor-widget elementor-widget-spacer\" data-id=\"a9c0f47\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3c484ca elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3c484ca\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d1e8faf\" data-id=\"d1e8faf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1f56177 elementor-widget elementor-widget-spacer\" data-id=\"1f56177\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d727677 elementor-widget elementor-widget-spacer\" data-id=\"d727677\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7bd41a3 elementor-widget elementor-widget-menu-anchor\" data-id=\"7bd41a3\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"unitedkingdom\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd99d02 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"dd99d02\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;slideInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">UNITED KINGDOM \ud83c\uddec\ud83c\udde7<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d2fa1c elementor-widget elementor-widget-text-editor\" data-id=\"7d2fa1c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #ffffff;\">Dundee<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-78e9480 elementor-widget elementor-widget-spacer\" data-id=\"78e9480\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div 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d=\"M15.6,13.2c0-0.1,4.3,0,6.7,0.5c2.4,0.5,5,1.9,5,2c0,0.1-2.7-0.8-5.1-1.4\tC19.9,13.7,15.7,13.3,15.6,13.2z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-36731d9\" data-id=\"36731d9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-67f897a elementor-widget elementor-widget-spacer\" data-id=\"67f897a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section 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d=\"M154.5,26.7c-0.1-0.1-4.6,0.3-7.2,0c-7.3-0.7-17-3.2-16.6-2.9c0.4,0.3,13.7,3.1,17,3.3\tC152.6,27.5,154.6,26.8,154.5,26.7z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M41.9,19.3c0,0,1.2-0.3,2.9-0.1c1.7,0.2,5.8,0.9,8.2,0.7c4.2-0.4,7.4-2.7,7-2.6\tc-0.4,0-4.3,2.2-8.6,1.9c-1.8-0.1-5.1-0.5-6.7-0.4S41.9,19.3,41.9,19.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M75.5,12.6c0.2,0.1,2-0.8,4.3-1.1c2.3-0.2,2.1-0.3,2.1-0.5c0-0.1-1.8-0.4-3.4,0\tC76.9,11.5,75.3,12.5,75.5,12.6z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M15.6,13.2c0-0.1,4.3,0,6.7,0.5c2.4,0.5,5,1.9,5,2c0,0.1-2.7-0.8-5.1-1.4\tC19.9,13.7,15.7,13.3,15.6,13.2z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-dc26599\" data-id=\"dc26599\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4445453 elementor-widget elementor-widget-text-editor\" data-id=\"4445453\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Over the past few decades, it has become clear that there is a relationship between type 2 diabetes mellitus (T2DM) and the inability of the heart to pump enough blood to meet the body&#8217;s needs, a condition called heart failure (HF). Although not all <b>patients with T2DM<\/b> develop disease affecting cardiomyopathy, they are <b>2.5 times more likely than patients without diabetes to develop heart failure<\/b>. As with diabetes, other factors such as hypertension, obesity, inflammation, and certain genetic disorders may cause patients to progress to heart failure, and their simultaneous presence has not yet isolated the specific contribution of type 2 diabetes mellitus to the development of cardiomyopathy.<\/p><p><span style=\"color: #99cc00;\">The hypothesis of the CARDIATEAM study<\/span> is that the changes leading to a decline in cardiac function in patients with T2DM (<b>diabetic cardiomyopathy<\/b>) is the result of the deregulation of biological mechanisms (specific signaling to be identified) leading to a particular cardiac dysfunction that is not the same as in other forms of heart failure.<\/p><p><span style=\"color: #99cc00;\">The primary objective<\/span> of this study is to determine to what extent the changes leading to diabetic cardiomyopathy are unique and distinct from other cardiac disorders.\u00a0<\/p><p><span style=\"color: #99cc00;\">Secondary objective<\/span> of this study: Once the uniqueness of diabetic cardiomyopathy is confirmed, this study will also aim to classify diabetic patients according to their higher or lower risk of developing heart failure in order to improve their treatment in relation to existing management schemes for this disease in Europe.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1afc4fc elementor-widget elementor-widget-text-editor\" data-id=\"1afc4fc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">The heart of our project CARDIATEAM is a clinical study on 1600 patients that are currently being recruited in 17 public hospitals in 5 European countries.<\/p><p style=\"text-align: center;\">ClinicalTrials.gov Identifier: NCT04303364<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6a3b8c2 elementor-widget elementor-widget-toggle\" data-id=\"6a3b8c2\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1111\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1111\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Expected benefits of this study<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1111\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1111\"><p>Overall, the results of this study aim to improve the clinical management of T2DM patients by exposing them to personalized preventive and therapeutic strategies to best preserve their cardiac function. I<\/p><p>Individually, each volunteer will benefit from a thorough and quality assessment of their cardiac, respiratory, renal and hepatic functions.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1112\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1112\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Categories of volunteers sought<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1112\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1112\"><p>In order to correctly characterize this diabetic cardiomyopathy, and to potentially differentiate it from other forms of cardiomyopathy, the CARDIATEAM study proposes to perform clinical examinations allowing a more in-depth characterization of the health status of T2DM patients and their non-diabetic controls while recruiting volunteers in the following 6 groups:<\/p><ul><li><p><b>Group 1:<\/b> patients without type 2 diabetes and without cardiac pathology defined as heart failure with preserved ejection fraction. This population will constitute a reference (control) group.<\/p><\/li><li><p><b>Group 2:<\/b> Patients without type 2 diabetes and with heart failure with preserved ejection fraction.<\/p><\/li><li><p><b>Group 3:<\/b> Patients with type 2 diabetes and without heart failure with preserved ejection fraction.<\/p><\/li><li><p><b>Group 4:<\/b> Patients with type 2 diabetes and heart failure with preserved ejection fraction.<\/p><\/li><li><p><b>Group 5:<\/b> Patients without type 2 diabetes with hypertrophic cardiomyopathy, which is another type of heart disease (HCM)<\/p><\/li><li><p><b>Group 6:<\/b> Patients with type 2 diabetes and hypertrophic cardiomyopathy.<\/p><\/li><\/ul><p>When comparing all these groups to each other:<\/p><p>&#8211; Patients without type 2 diabetes will be the referrers\/controls of those with diabetes.<\/p><p>&#8211; Patients without heart failure with preserved ejection fraction \u00b1 T2DM will be the referents\/controls of those with heart failure with preserved ejection fraction.<\/p><p>&#8211; Patients with hypertrophic cardiomyopathy will serve as comparators to the groups of patients with preserved ejection fraction heart failure to refine and better define the uniqueness of preserved ejection fraction heart failure compared with other types of myocardial dysfunction.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1113\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1113\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What examinations will be performed in the study?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1113\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1113\"><p>Volunteers wishing to participate in CARDIATEAM will undergo a screening visit to determine if they meet the inclusion\/entry criteria for the study.\u00a0<\/p><p>If so, they will follow the following pathway followed by:<\/p><p>&#8211; a <b>visit 1<\/b> V1 called <i>Inclusion<\/i>: routine clinical examinations combined with clinical grade research examinations, including extensive imaging to assess the volunteer&#8217;s cardiac, respiratory and liver function. This characterization will be coupled with blood and urine samples to assess renal function and perform innovative biological analyses.<\/p><p>&#8211; <b>two follow-up surveys<\/b> conducted by telephone after one and two years after V1<\/p><p>&#8211; a <b>second visit<\/b>, called <i>End of Study<\/i>, 3 years after V1<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1114\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-1114\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quels sont les h\u00f4pitaux concern\u00e9s ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1114\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-1114\"><p><span style=\"color: #8ec044;\"><strong>France :<\/strong> <\/span><\/p><p>&#8211; H\u00f4pital Henri Mondor \u00e0 Cr\u00e9teil<\/p><p>&#8211; H\u00f4pital Cochin \u00e0 Paris<\/p><p>&#8211; H\u00f4pital Lariboisi\u00e8re \u00e0 Paris<\/p><p>&#8211; H\u00f4pital Hospices Civiles de Lyon<\/p><p>&#8211; H\u00f4pital d&#8217;Assistance Publique Marseille\u00a0<\/p><p>&#8211; H\u00f4pital de Nantes<\/p><p>&#8211; H\u00f4pital de Grenoble<\/p><p>\u00a0<\/p><p>Espagne :\u00a0<\/p><p>&#8211; Hospital General Universitario Maranon<\/p><p>&#8211; H\u00f4pital Clinic Barcelona<\/p><p>&#8211; H\u00f4pital Val d&#8217;H\u00e9bron Barcelone<\/p><p>\u00a0<\/p><p>Allemagne :<\/p><p>&#8211; Universit\u00e4tsklinikum Aachen<\/p><p>&#8211; Universit\u00e4tsklinikum Heidelberg<\/p><p>\u00a0<\/p><p>Pays-Bas :<\/p><p>&#8211; H\u00f4pital Maastricht<\/p><p>&#8211; H\u00f4pital d&#8217;Utrecht<\/p><p>&#8211; H\u00f4pital de Groningue<\/p><p>&#8211; H\u00f4pital d&#8217;Amsterdam<\/p><p>\u00a0<\/p><p>Royaume-Uni :<\/p><p>H\u00f4pital Ninewells et facult\u00e9 de m\u00e9decine de Dundee<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1115\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-1115\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How to express your interest in participating in the CARDIATEAM study?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1115\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-1115\"><p>If you think you belong to one of the 6 volunteer groups detailed above and you live near one of the recruitment centers listed above, please feel free to inquire about the possibility of participating in the study as a volunteer.<\/p><p>\u00a0Please contact us at the following number: XXX.<\/p><p>Our team will be happy to explain the study to you in detail and may be able to arrange an appointment for an eligibility visit.<\/p><p>While thanking you for your commitment to clinical research, we hope to see you soon.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ff2cc4 elementor-widget elementor-widget-spacer\" data-id=\"2ff2cc4\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0d95e6 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f0d95e6\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg 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M113.4,10.2c1.2,0,2.2,0.9,2.2,3.2s-0.1,3.2-1.3,3.2s-3.1-1.4-3.1-3.2S112.2,10.2,113.4,10.2z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f91941e elementor-widget elementor-widget-spacer\" data-id=\"f91941e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3da3320 elementor-widget elementor-widget-spacer\" data-id=\"3da3320\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-68f1aca elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"68f1aca\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-320f83b\" data-id=\"320f83b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13c022c elementor-widget elementor-widget-spacer\" data-id=\"13c022c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0164363 elementor-widget elementor-widget-spacer\" data-id=\"0164363\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ecf144 elementor-widget elementor-widget-menu-anchor\" data-id=\"8ecf144\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"deutschland\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98a9a6c elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"98a9a6c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;slideInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">DEUTSCHLAND \ud83c\udde9\ud83c\uddea\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33b9b4f elementor-widget elementor-widget-text-editor\" data-id=\"33b9b4f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #ffffff;\">Aachen and Heidelberg<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee54ebc elementor-widget elementor-widget-spacer\" data-id=\"ee54ebc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3cdff06 elementor-widget elementor-widget-spacer\" data-id=\"3cdff06\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-73b986f elementor-section-stretched elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"73b986f\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;wave-brush&quot;,&quot;shape_divider_bottom&quot;:&quot;wave-brush&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 283.5 27.8\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" 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d=\"M15.6,13.2c0-0.1,4.3,0,6.7,0.5c2.4,0.5,5,1.9,5,2c0,0.1-2.7-0.8-5.1-1.4\tC19.9,13.7,15.7,13.3,15.6,13.2z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8b276d5\" data-id=\"8b276d5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1a0c1a1 elementor-widget elementor-widget-text-editor\" data-id=\"1a0c1a1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In den letzten Jahrzehnten wurde deutlich, dass es einen Zusammenhang zwischen Diabetes mellitus Typ 2 (T2DM) und der Unf\u00e4higkeit des Herzens gibt, gen\u00fcgend Blut zu pumpen, um den Bedarf des K\u00f6rpers zu decken, ein Zustand, der als Herzinsuffizienz (HF) bezeichnet wird. Obwohl nicht alle <b>Patienten mit T2DM<\/b> eine kardiomyopathische Erkrankung entwickeln, ist die Wahrscheinlichkeit, dass sie eine Herzinsuffizienz entwickeln, <b>2,5 Mal h\u00f6her als<\/b> <b>bei Patienten ohne Diabetes<\/b>. Wie bei Diabetes k\u00f6nnen auch andere Faktoren wie Bluthochdruck, Fettleibigkeit, Entz\u00fcndungen und bestimmte genetische St\u00f6rungen dazu f\u00fchren, dass Patienten eine Herzinsuffizienz entwickeln, und ihr gleichzeitiges Vorhandensein hat den spezifischen Beitrag des Typ-2-Diabetes mellitus zur Entwicklung einer Kardiomyopathie noch nicht isoliert.<\/p><p><span style=\"color: #99cc00;\">Die Hypothese der CARDIATEAM-Studie<\/span> lautet, dass die Ver\u00e4nderungen, die zu einer Verschlechterung der Herzfunktion bei Patienten mit T2DM (<b>diabetische Kardiomyopathie<\/b>) f\u00fchren, das Ergebnis einer Deregulierung biologischer Mechanismen (spezifische Signal\u00fcbertragung muss noch identifiziert werden) sind, die zu einer besonderen Funktionsst\u00f6rung des Herzens f\u00fchren, die sich von anderen Formen der Herzinsuffizienz unterscheidet.<\/p><p><span style=\"color: #99cc00;\">Das prim\u00e4re Ziel dieser Studie<\/span> ist es, festzustellen, inwieweit die Ver\u00e4nderungen, die zur diabetischen Kardiomyopathie f\u00fchren, einzigartig sind und sich von anderen Herzerkrankungen unterscheiden.\u00a0<\/p><p><span style=\"color: #99cc00;\">Sekund\u00e4res Ziel dieser Studie:<\/span> Sobald die Einzigartigkeit der diabetischen Kardiomyopathie best\u00e4tigt ist, wird diese Studie auch darauf abzielen, diabetische Patienten nach ihrem h\u00f6heren oder niedrigeren Risiko, eine Herzinsuffizienz zu entwickeln, zu klassifizieren, um ihre Behandlung im Vergleich zu den bestehenden Behandlungssystemen f\u00fcr diese Krankheit in Europa zu verbessern.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-666e101 elementor-widget elementor-widget-text-editor\" data-id=\"666e101\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">Das Herzst\u00fcck unseres Projekts CARDIATEAM ist eine klinische Studie mit 1600 Patienten, die derzeit in 17 \u00f6ffentlichen Krankenh\u00e4usern in 5 europ\u00e4ischen L\u00e4ndern rekrutiert werden.<\/p><p style=\"text-align: center;\">Kennung von ClinicalTrials.gov: NCT04303364<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efcf7c0 elementor-widget elementor-widget-toggle\" data-id=\"efcf7c0\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2511\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2511\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Erwarteter Nutzen dieser Studie<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2511\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2511\"><p>Insgesamt zielen die Ergebnisse dieser Studie darauf ab, das klinische Management von T2DM-Patienten zu verbessern, indem sie ihnen personalisierte Pr\u00e4ventions- und Therapiestrategien vorschlagen, um ihre Herzfunktion bestm\u00f6glich zu erhalten.\u00a0<\/p><p>Jeder einzelne Proband wird von einer gr\u00fcndlichen und qualitativ hochwertigen Bewertung seiner Herz-, Atem-, Nieren- und Leberfunktionen profitieren.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2512\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2512\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Gesuchte Kategorien von Probanden<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2512\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2512\"><p>Um die diabetische Kardiomyopathie richtig zu charakterisieren und sie m\u00f6glicherweise von anderen Formen der Kardiomyopathie zu unterscheiden, sollen im Rahmen der CARDIATEAM-Studie klinische Untersuchungen durchgef\u00fchrt werden, die eine eingehendere Charakterisierung des Gesundheitszustands von T2DM-Patienten und ihren nicht-diabetischen Kontrollpersonen erm\u00f6glichen, wobei Probanden in den folgenden 6 Gruppen rekrutiert warden:<\/p><ul><li><b>Gruppe 1:<\/b> Patienten ohne Typ-2-Diabetes und ohne kardiale Pathologie, definiert als Herzinsuffizienz mit erhaltener Ejektionsfraktion. Diese Population wird eine Referenzgruppe (Kontrollgruppe) darstellen.<\/li><li><b>Gruppe 2:<\/b> Patienten ohne Typ-2-Diabetes und mit Herzinsuffizienz mit erhaltener Auswurffraktion<\/li><li><b>Gruppe 3:<\/b> Patienten mit Typ-2-Diabetes und ohne Herzinsuffizienz mit erhaltener Auswurffraktion.<\/li><li><b>Gruppe 4:<\/b> Patienten mit Typ-2-Diabetes und Herzinsuffizienz mit erhaltener Auswurffraktion.<\/li><li><b>Gruppe 5:<\/b> Patienten ohne Typ-2-Diabetes mit hypertropher Kardiomyopathie, einer anderen Form der Herzerkrankung (HCM)<\/li><li><b>Gruppe 6:<\/b> Patienten mit Typ-2-Diabetes und hypertropher Kardiomyopathie.<\/li><\/ul><p>\u00a0<\/p><p>Wenn man alle diese Gruppen miteinander vergleicht:<\/p><p>&#8211;\u00a0 \u00a0 Patienten ohne Typ-2-Diabetes sind die Bezugspersonen\/Kontrollpersonen derjenigen mit Diabetes.<\/p><p>&#8211; Patienten ohne Herzinsuffizienz mit erhaltener Auswurffraktion \u00b1 T2DM sind die Bezugspersonen\/Kontrollpersonen der Patienten mit Herzinsuffizienz mit erhaltener Auswurffraktion.<\/p><p>&#8211; Patienten mit hypertropher Kardiomyopathie werden als Vergleichspersonen zu den Patientengruppen mit Herzinsuffizienz mit erhaltener Auswurffraktion dienen, um die Einzigartigkeit der Herzinsuffizienz mit erhaltener Auswurffraktion im Vergleich zu anderen Arten von Myokardfunktionsst\u00f6rungen zu pr\u00e4zisieren und besser zu definieren.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2513\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2513\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Welche Untersuchungen werden im Rahmen der Studie durchgef\u00fchrt?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2513\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2513\"><p>Freiwillige, die an CARDIATEAM teilnehmen m\u00f6chten, werden einer Screening-Untersuchung unterzogen, um festzustellen, ob sie die Einschluss-\/Teilnahmekriterien f\u00fcr die Studie erf\u00fcllen.\u00a0<\/p><p>Ist dies der Fall, folgen sie dem folgenden Ablauf:\u00a0<\/p><p>&#8211; <b>eine Visite 1<\/b> V1, genannt <i>Einschluss<\/i>: klinische Routineuntersuchungen in Kombination mit klinischen Forschungsuntersuchungen, einschlie\u00dflich umfangreicher Bildgebung zur Beurteilung der Herz-, Atemwegs- und Leberfunktion des Probanden. Diese Charakterisierung wird mit Blut- und Urinproben kombiniert, um die Nierenfunktion zu beurteilen und innovative biologische Analysen durchzuf\u00fchren.<\/p><p>&#8211; <b>zwei telefonische Nachuntersuchungen<\/b> nach einem und zwei Jahren nach V1<\/p><p>&#8211; ein <b>zweiter Besuch<\/b>, genannt <i>End of Study<\/i>, 3 Jahre nach V1<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2514\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2514\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Wer sind die beteiligten Krankenh\u00e4user?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2514\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2514\"><p>Frankreich:\u00a0<\/p><p>&#8211; Krankenhaus Henri Mondor in Creteil<\/p><p>&#8211; Krankenhaus Cochin in Paris<\/p><p>&#8211; Krankenhaus Lariboisi\u00e8re in Paris<\/p><p>&#8211; Krankenhaus Hospices Civiles in Lyon<\/p><p>&#8211; Krankenhaus d&#8217;Assistance Publique Marseille\u00a0<\/p><p>&#8211; Krankenhaus von Nantes<\/p><p>&#8211; Krankenhaus von Grenoble<\/p><p>\u00a0<\/p><p>Spanien:\u00a0<\/p><p>&#8211; Krankenhaus General Universitario Maranon<\/p><p>&#8211; Klinikum Barcelona<\/p><p>&#8211; Krankenhaus Val d&#8217;H\u00e9bron Barcelona<\/p><p>\u00a0<\/p><p><span style=\"color: #99cc00;\"><strong>Deutschland:<\/strong><\/span><\/p><p>&#8211; Universit\u00e4tsklinikum Aachen<\/p><p>&#8211; Universit\u00e4tsklinikum Heidelberg<\/p><p>\u00a0<\/p><p>Niederlande:<\/p><p>&#8211; Krankenhaus Maastricht<\/p><p>&#8211; Krankenhaus Utrecht<\/p><p>&#8211; Krankenhaus Groningen<\/p><p>&#8211; Krankenhaus Amsterdam<\/p><p>\u00a0<\/p><p>Vereinigtes K\u00f6nigreich:<\/p><p>&#8211; Ninewells Hospital und Medizinische Fakult\u00e4t Dundee<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2515\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2515\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Wie k\u00f6nnen Sie Ihr Interesse an einer Teilnahme an der CARDIATEAM-Studie bekunden?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2515\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2515\"><p>Wenn Sie glauben, zu einer der sechs oben genannten Gruppen von Freiwilligen zu geh\u00f6ren, und in der N\u00e4he eines der oben genannten Rekrutierungszentren wohnen, k\u00f6nnen Sie sich gerne nach der M\u00f6glichkeit erkundigen, als Freiwilliger an der Studie teilzunehmen.<\/p><p>\u00a0Bitte kontaktieren Sie uns unter der folgenden Nummer: XXX.<\/p><p>Unser Team wird Ihnen die Studie gerne im Detail erl\u00e4utern und kann eventuell einen Termin f\u00fcr einen Eignungstest vereinbaren.<\/p><p>Wir danken Ihnen f\u00fcr Ihr Engagement in der klinischen Forschung und hoffen, Sie bald wiederzusehen.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1913e92 elementor-widget elementor-widget-spacer\" data-id=\"1913e92\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33c56d7 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"33c56d7\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;xMidYMid meet&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 126 26&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M3,10.2c2.6,0,2.6,2,2.6,3.2S4.4,16.5,3,16.5s-3-1.4-3-3.2S0.4,10.2,3,10.2z M18.8,10.2c1.7,0,3.2,1.4,3.2,3.2s-1.4,3.2-3.2,3.2c-1.7,0-3.2-1.4-3.2-3.2S17,10.2,18.8,10.2z M34.6,10.2c1.5,0,2.6,1.4,2.6,3.2s-0.5,3.2-1.9,3.2c-1.5,0-3.4-1.4-3.4-3.2S33.1,10.2,34.6,10.2z M50.5,10.2c1.7,0,3.2,1.4,3.2,3.2s-1.4,3.2-3.2,3.2c-1.7,0-3.3-0.9-3.3-2.6S48.7,10.2,50.5,10.2z M66.2,10.2c1.5,0,3.4,1.4,3.4,3.2s-1.9,3.2-3.4,3.2c-1.5,0-2.6-0.4-2.6-2.1S64.8,10.2,66.2,10.2z M82.2,10.2c1.7,0.8,2.6,1.4,2.6,3.2s-0.1,3.2-1.6,3.2c-1.5,0-3.7-1.4-3.7-3.2S80.5,9.4,82.2,10.2zM98.6,10.2c1.5,0,2.6,0.4,2.6,2.1s-1.2,4.2-2.6,4.2c-1.5,0-3.7-0.4-3.7-2.1S97.1,10.2,98.6,10.2z M113.4,10.2c1.2,0,2.2,0.9,2.2,3.2s-0.1,3.2-1.3,3.2s-3.1-1.4-3.1-3.2S112.2,10.2,113.4,10.2z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a23b492 elementor-widget elementor-widget-spacer\" data-id=\"a23b492\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7816526 elementor-widget elementor-widget-spacer\" data-id=\"7816526\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d16f02d elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d16f02d\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-71bf131\" data-id=\"71bf131\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1033a25 elementor-widget elementor-widget-spacer\" data-id=\"1033a25\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14f8937 elementor-widget elementor-widget-spacer\" data-id=\"14f8937\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d2a38e elementor-widget elementor-widget-menu-anchor\" data-id=\"2d2a38e\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"spain\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d21b06e elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"d21b06e\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;slideInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">SPAIN \ud83c\uddea\ud83c\uddf8<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d55913d elementor-widget elementor-widget-text-editor\" data-id=\"d55913d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #ffffff;\">Madrid and Barcelona<br \/><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-330518a elementor-widget elementor-widget-spacer\" data-id=\"330518a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49b27bf elementor-widget elementor-widget-spacer\" data-id=\"49b27bf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div 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d=\"M227.4,9.8c-0.2-0.1-4.5-1-9.5-1.2c-5-0.2-12.7,0.6-12.3,0.5c0.3-0.1,5.9-1.8,13.3-1.2\tS227.6,9.9,227.4,9.8z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M204.5,13.4c-0.1-0.1,2-1,3.2-1.1c1.2-0.1,2,0,2,0.3c0,0.3-0.1,0.5-1.6,0.4\tC206.4,12.9,204.6,13.5,204.5,13.4z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M201,10.6c0-0.1-4.4,1.2-6.3,2.2c-1.9,0.9-6.2,3.1-6.1,3.1c0.1,0.1,4.2-1.6,6.3-2.6\tS201,10.7,201,10.6z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M154.5,26.7c-0.1-0.1-4.6,0.3-7.2,0c-7.3-0.7-17-3.2-16.6-2.9c0.4,0.3,13.7,3.1,17,3.3\tC152.6,27.5,154.6,26.8,154.5,26.7z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M41.9,19.3c0,0,1.2-0.3,2.9-0.1c1.7,0.2,5.8,0.9,8.2,0.7c4.2-0.4,7.4-2.7,7-2.6\tc-0.4,0-4.3,2.2-8.6,1.9c-1.8-0.1-5.1-0.5-6.7-0.4S41.9,19.3,41.9,19.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M75.5,12.6c0.2,0.1,2-0.8,4.3-1.1c2.3-0.2,2.1-0.3,2.1-0.5c0-0.1-1.8-0.4-3.4,0\tC76.9,11.5,75.3,12.5,75.5,12.6z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M15.6,13.2c0-0.1,4.3,0,6.7,0.5c2.4,0.5,5,1.9,5,2c0,0.1-2.7-0.8-5.1-1.4\tC19.9,13.7,15.7,13.3,15.6,13.2z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-467e1c2\" data-id=\"467e1c2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bfd673c elementor-widget elementor-widget-text-editor\" data-id=\"bfd673c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En las \u00faltimas d\u00e9cadas, se ha establecido una relaci\u00f3n entre la DMT2 y la incapacidad del coraz\u00f3n para bombear suficiente sangre para satisfacer las necesidades del organismo, una afecci\u00f3n denominada insuficiencia cardiaca (IC). De hecho, los pacientes con DMT2 tienen 2,5 veces m\u00e1s probabilidades que los no diab\u00e9ticos de desarrollar insuficiencia cardiaca. Otros factores a menudo asociados a la DMT2, como la hipertensi\u00f3n, la obesidad, la inflamaci\u00f3n y ciertos trastornos gen\u00e9ticos, tambi\u00e9n contribuyen a la progresi\u00f3n hacia la insuficiencia cardiaca. Queda por demostrar la contribuci\u00f3n espec\u00edfica de la DMT2 al desarrollo de la miocardiopat\u00eda.<\/p><p><span style=\"color: #99cc00;\">La hip\u00f3tesis del estudio CARDIATEAM<\/span> es que los cambios que conducen a un deterioro de la funci\u00f3n cardiaca en pacientes con DMT2 (miocardiopat\u00eda diab\u00e9tica) son el resultado de la desregulaci\u00f3n de mecanismos biol\u00f3gicos (se\u00f1alizaci\u00f3n espec\u00edfica por identificar) que conducen a una disfunci\u00f3n cardiaca \u00fanica y, por tanto, distinta de otras formas de insuficiencia cardiaca.<\/p><p><span style=\"color: #99cc00;\">El principal objetivo de CARDIATEAM<\/span> es determinar los mecanismos que conducen al desarrollo de la cardiomiopat\u00eda espec\u00edfica de los pacientes diab\u00e9ticos de tipo 2.<\/p><p><span style=\"color: #99cc00;\">Los objetivos secundarios de CARDIATEAM<\/span> son mejorar la puntuaci\u00f3n predictiva del desarrollo de insuficiencia cardiaca e identificar nuevas dianas terap\u00e9uticas para desarrollar tratamientos espec\u00edficos de la miocardiopat\u00eda diab\u00e9tica y mejorar as\u00ed su tratamiento.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65e67a7 elementor-widget elementor-widget-text-editor\" data-id=\"65e67a7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">CARDIATEAM es un estudio cl\u00ednico en el que participan 1600 voluntarios reclutados actualmente en 16 hospitales p\u00fablicos de 5 pa\u00edses europeos.<br \/>Identificador ClinicalTrials.gov : NCT04303364<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c71577b elementor-widget elementor-widget-toggle\" data-id=\"c71577b\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2081\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2081\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Beneficios esperados de este estudio<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2081\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2081\"><p>En conjunto, los resultados de este estudio pretenden mejorar el manejo cl\u00ednico de los pacientes con DMT2 alertando de la existencia de miocardiopat\u00eda diab\u00e9tica, proponiendo herramientas de detecci\u00f3n precoz y mejorando las puntuaciones predictivas de progresi\u00f3n a insuficiencia cardiaca. <br \/>Individualmente, cada voluntario se beneficiar\u00e1 de una evaluaci\u00f3n cl\u00ednica, biol\u00f3gica y radiol\u00f3gica completa destinada a evaluar las funciones cardiaca, metab\u00f3lica, respiratoria, renal y hep\u00e1tica.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2082\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2082\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Categor\u00edas de voluntarios buscados<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2082\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2082\"><p>Para definir mejor la cardiomiopat\u00eda diab\u00e9tica y diferenciarla de otras formas de cardiomiopat\u00eda, el estudio CARDIATEAM propone realizar ex\u00e1menes cl\u00ednicos que permitan caracterizar en profundidad el estado de salud de voluntarios diab\u00e9ticos y no diab\u00e9ticos que ser\u00e1n reclutados en los 6 grupos siguientes :<\/p><ul><li><strong>Grupo 1 :<\/strong> Pacientes sin DMT2 y sin patolog\u00eda cardiaca. Esta poblaci\u00f3n constituir\u00e1 un grupo de referencia (control).<\/li><li><strong>Grupo 2 :<\/strong> Pacientes sin DMT2 y con insuficiencia cardiaca con fracci\u00f3n de eyecci\u00f3n preservada.<\/li><li><strong>Grupo 3 :<\/strong> Pacientes con DMT2 y sin insuficiencia cardiaca con fracci\u00f3n de eyecci\u00f3n preservada.<\/li><li><strong>Grupo 4 :<\/strong> Pacientes con DMT2 e insuficiencia cardiaca con fracci\u00f3n de eyecci\u00f3n preservada.<\/li><li><strong>Grupo 5 :<\/strong> Pacientes sin DMT2 con miocardiopat\u00eda hipertr\u00f3fica (MCH)<\/li><li><strong>Grupo 6 :<\/strong> pacientes con DMT2 y MCH.<\/li><\/ul><p>Para determinar las caracter\u00edsticas de la cardiomiopat\u00eda diab\u00e9tica, se analizar\u00e1 a los voluntarios participantes en el estudio mediante nuevas t\u00e9cnicas estad\u00edsticas no supervisadas, con el fin de redefinir mejor los grupos de pacientes con riesgo de insuficiencia cardiaca.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2083\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2083\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">\u00bfQu\u00e9 pruebas se realizar\u00e1n en el marco del estudio?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2083\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2083\"><p>\u27a1\ufe0f Los voluntarios que deseen participar en CARDIATEAM ser\u00e1n reclutados sobre la base de una fracci\u00f3n de eyecci\u00f3n ventricular izquierda &gt;50% y la ausencia de patolog\u00eda cardiaca isqu\u00e9mica (sin antecedentes de infarto de miocardio o angina de pecho, sin lesiones coronarias significativas). Estos criterios se verificar\u00e1n durante la <span style=\"text-decoration: underline;\">visita de cribado<\/span> previa a la inclusi\u00f3n en el estudio. La duraci\u00f3n de la participaci\u00f3n en CARDIATEAM ser\u00e1 de 3 a\u00f1os y excluir\u00e1 la participaci\u00f3n del voluntario en un ensayo farmacol\u00f3gico o intervencionista.<\/p><p>\u27a1\ufe0f En la <span style=\"text-decoration: underline;\">visita de inclusi\u00f3n<\/span>, se realizar\u00e1n ex\u00e1menes cl\u00ednicos rutinarios en combinaci\u00f3n con pruebas detalladas de la funci\u00f3n cardiaca (ecocardiograf\u00eda combinada con im\u00e1genes de deformaci\u00f3n, resonancia magn\u00e9tica), pruebas de la funci\u00f3n respiratoria, medici\u00f3n de la composici\u00f3n corporal, cribado de la apnea del sue\u00f1o, retinograma y toma de muestras de sangre y orina para identificar nuevos biomarcadores de la cardiomiopat\u00eda diab\u00e9tica.<\/p><p>\u27a1\ufe0f Se realizar\u00e1n dos <span style=\"text-decoration: underline;\">encuestas de seguimiento<\/span> por tel\u00e9fono uno y dos a\u00f1os despu\u00e9s de la visita de inclusi\u00f3n<\/p><p>\u27a1\ufe0f Se realizar\u00e1 una <span style=\"text-decoration: underline;\">visita al final del estudio<\/span> tres a\u00f1os despu\u00e9s de la visita de inclusi\u00f3n, que incluir\u00e1 una ecograf\u00eda y un chequeo biol\u00f3gico est\u00e1ndar.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2084\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2084\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">\u00bfQu\u00e9 hospitales est\u00e1n afectados en Espa\u00f1a?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2084\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2084\"><p>&#8211; Hospital General Universitario Maranon : Prof Javier Bermejo <br \/>&#8211; Hospital Cl\u00ednic de Barcelona : Prof Palomarez-Rodriguez <br \/>&#8211; Hospital Val d&#8217;Hebron Barcelona : Prof Marta Stiges<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2085\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2085\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">\u00bfC\u00f3mo expresar su inter\u00e9s en participar en el estudio CARDIATEAM?\t<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2085\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2085\"><p>Si cree que podr\u00eda encajar en uno de los 6 grupos de voluntarios detallados anteriormente y vive cerca de uno de los centros de reclutamiento indicados, no dude en preguntar sobre la posibilidad de participar en el estudio como voluntario.<\/p><p>P\u00f3ngase en contacto con los m\u00e9dicos responsables del estudio : <strong>cardiateam.imrb@inserm.fr<\/strong>\u00a0<\/p><p>Nuestro equipo estar\u00e1 encantado de explicarle en detalle el estudio y concertar una cita para una visita de elegibilidad.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22d9576 elementor-widget elementor-widget-spacer\" data-id=\"22d9576\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3792c6e elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3792c6e\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: 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class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5bb392f elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5bb392f\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4c78731\" data-id=\"4c78731\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-404fd0a elementor-widget elementor-widget-spacer\" data-id=\"404fd0a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5c199aa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5c199aa\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-15b67e1\" data-id=\"15b67e1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-227c12d elementor-widget elementor-widget-heading\" data-id=\"227c12d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Acknowledgement<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fd3a979 elementor-widget elementor-widget-text-editor\" data-id=\"fd3a979\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This project has received funding from the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement No 821508.\u00a0<br \/>See more on\u00a0<a href=\"https:\/\/cordis.europa.eu\/project\/rcn\/222552\/factsheet\/en\" target=\"_blank\" rel=\"noopener\">Cordis portal<\/a>.\u00a0<br \/>The contents of this website and the view expressed in the news and publications are the sole responsibility of the authors and under no circumstances can be regarded as reflecting the position of the European Union.<\/p><p>Read our <a href=\"http:\/\/cardiateam.eu\/index.php\/politique-de-confidentialite\/\" target=\"_blank\" rel=\"noopener\">privacy policy<\/a> and <a href=\"http:\/\/cardiateam.eu\/index.php\/legal-notice\/\" target=\"_blank\" rel=\"noopener\">legal notice<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-03d9bdb elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"03d9bdb\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg 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M113.4,10.2c1.2,0,2.2,0.9,2.2,3.2s-0.1,3.2-1.3,3.2s-3.1-1.4-3.1-3.2S112.2,10.2,113.4,10.2z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d674425 elementor-widget elementor-widget-advanced-text-block\" data-id=\"d674425\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"advanced-text-block.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"futurio_extra_adv_text_block \" ><div class=\"text-content-block\"><p>Website designed by: <strong>Vanmala VONGKINGKEO<\/strong><\/p><p>Icons made by <a title=\"Twitter\" href=\"https:\/\/www.flaticon.com\/authors\/twitter\">Twitter<\/a> from <a title=\"Flaticon\" href=\"https:\/\/www.flaticon.com\/\">www.flaticon.com<\/a><\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>OUR CLINICAL STUDY Acc\u00e9der aux projets utilisant les donn\u00e9es issues de la recherche Cardiateam(portail de transparence) \ud83c\uddeb\ud83c\uddf7 \ud83c\uddec\ud83c\udde7 \ud83c\udde9\ud83c\uddea \ud83c\uddea\ud83c\uddf8 \ud83c\uddeb\ud83c\uddf7 L&#8217;objectif principal de cette \u00e9tude est de d\u00e9terminer dans quelle mesure les changements conduisant \u00e0 un d\u00e9clin de la fonction cardiaque chez les patients atteints de DT2 (cardiomyopathie diab\u00e9tique) sont uniques et distincts des&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-664","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Clinical Study - Cardiateam<\/title>\n<meta name=\"description\" content=\"Learn more about the CARDIATEAM clinical study.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cardiateam.eu\/index.php\/clinical-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical Study - Cardiateam\" \/>\n<meta property=\"og:description\" content=\"Learn 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